原著論文2023
December 24, 2023
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- Common germline risk variants impact somatic alterations and clinical features across cancers
Namba S, Saito Y, Kogure Y, Masuda T, Bondy ML, Gharahkhani P, Gockel I, Heider D, Hillmer A, Jankowski J, MacGregor S, Maj C, Melin B, Ostrom QT, Palles C, Schumacher J, Tomlinson I, Whiteman DC, Okada Y, Kataoka K.
Cancer Res, 2023, 117(2), p.260-288 - Optimization of the proliferation and persistency of CAR T cells derived from human induced pluripotent stem cells
Ueda T, Shiina S, Iriguchi S, Terakura S, Kawai Y, Kabai R, Sakamoto S, Watanabe A, Ohara K, Wang B, Xu H, Minagawa A, Hotta A, Woltjen K, Uemura Y, Kodama Y, Seno H, Nakatsura T, Tamada K, Kaneko S.
Nat Biomed Eng., 2023, 7(1), p.24-37 - The role of Kras and canonical Wnt pathways for tumorigenesis of extrahepatic biliary system
Nagao M, Fukuda A, Seno H.
Oncotarget, 2023, 14, p.54-56 - Identification of novel senescent markers in small extracellular vesicles
Misawa T, Hitomi K, Miyata K, Tanaka Y, Fujii R, Chiba M, Loo TM, Hanyu A, Kawasaki H, Kato H, Maezawa Y, Yokote K, Nakamura AJ, Ueda K, Yaegashi N, & *Takahashi A.
International Journal of Molecular Sciences, 2023, 24(3), p.2421 - An atlas of substrate specificities for the human serine/threonine kinome
Johnson JL, Yaron TM, Huntsman EM, Kerelsky A, Song J, Regev A, Lin TY, Liberatore K, Cizin DM, Cohen BM, Vasan N, Ma Y, Krismer K, Robles JT, van de Kooij B, van Vlimmeren AE, Andrée-Busch N, Käufer NF, Dorovkov MV, Ryazanov AG, Takagi Y, Kastenhuber ER, Goncalves MD, Hopkins BD, Elemento O, Taatjes DJ, Maucuer A, Yamashita A, Degterev A, Uduman M, Lu J, Landry SD, Zhang B, Cossentino I, Linding R, Blenis J, Hornbeck PV, Turk BE, Yaffe MB, Cantley LC.
Nature, 2023, 613(7945), p.759-766 - Evolutional transition of HBV genome during the persistent infection determined by single-molecule real-time sequencing
Arasawa S, Takeda H, Takai A, Iguchi E, Eso Y, Shimizu T, Takahashi K, Yamashita T, Ueda Y, Marusawa H, Seno H.
Hepatol Commun, 2023, 7(3), e00407 - Polysulfide Serves as a Hallmark of Desmoplastic Reaction to Differentially Diagnose Ductal Carcinoma In Situ and Invasive Breast Cancer by SERS Imaging
Kubo A, Masugi Y, Hase T, Nagashima K, Kawai Y, Takizawa M, Hishiki T, Shiota M, Wakui M, Kitagawa Y, Kabe Y, Sakamoto M, Yachie A, Hayashida T, Suematsu M.
Antioxidants (Basel), 2023, 12(2), p.240 - Mitochondria directly sense osmotic stress to trigger rapid metabolic remodeling via regulation of pyruvate dehydrogenase (PDH) phosphorylation
Ikizawa T, Ikeda K, Arita M, Kitajima S, Soga T, Ichijo H. and Naguro I.
J. Biol. Chem., 2023, 299(2), p.102837 - Ror1 is expressed inducibly by Notch and hypoxia signaling and regulates stem cell-like property of glioblastoma cells
Ishikawa T, Ogura Y, Tanaka K, Nagashima H, Sasayama T, Endo M, Minami Y.
Cancer Sci., 2023, 114(2), p.561-573 - Pivotal role for S-nitrosylation of DNA methyltransferase 3B in epigenetic regulation of tumorigenesis
Okuda K, Nakahara K, Ito A, Iijima Y, Nomura R, Kumar A, Fujikawa K, Adachi K, Shimada Y, Fujio S, Yamamoto R, Takasugi N, Onuma K, Osaki M, Okada F, Ukegawa T, Takeuchi Y, Yasui N, Yamashita A, Marusawa H, Matsushita Y, Katagiri T, Shibata T, Uchida K, Niu SY, Lang BN, Nakamura T, Zhang JY, Lipton SA, Uehara T.
Nature Communications, 2023, 14(1), p.621 - Blue light induces apoptosis and autophagy by promoting ROS-mediated mitochondrial dysfunction in synovial sarcoma
Takeuchi M, Nishisho T, Toki S, Kawaguchi S, Tamaki S, Oya T, Uto Y, Katagiri T, Sairyo K.
Cancer Med., 12(8), p.9668-9683 - p53 protects against formation of extrahepatic biliary precancerous lesions in the context of oncogenic Kras
Nagao M, Mizukoshi K, Nakayama S, Namikawa M, Hiramatsu Y, Maruno T, Nakanishi Y, Tsuruyama T, Fukuda A, Seno H, Nagao M, Mizukoshi K, Nakayama S, Namikawa M, Hiramatsu Y, Maruno T, Nakanishi Y, Tsuruyama T, Fukuda A, Seno H.
Onncotarget., 2023, 14, p.276-279 - Differential involvement of LUBAC-mediated linear ubiquitination in intestinal epithelial cells and macrophages during intestinal inflammation
Sakamoto Y, Sasaki K, Omatsu M, Hamada K, Nakanishi Y, Itatani Y, Kawada K, Obama K, Seno H, Iwai K.
J Pathol, 2023, 259(3), p.304-317 - Comparison of hepatic responses to glucose perturbation between healthy and obese mice based on the edge type of network structures
Ito Y, Uda S, Kokaji T, Suzuki Y, Hirayama A, Soga T, Kuroda S, Kubota H.
Sci. Rep., 13(1), p.4758 - Lack of impact of the ALDH2 rs671 variant on breast cancer development in Japanese BRCA1/2-mutation carriers
Mori T, Okamoto Y, Mu A, Ide Y, Yoshimura A, Senda N, Inagaki-Kawata Y, Kawashima M, Kitao H, Tokunaga E, Miyoshi Y, Ohsumi S, Tsugawa K, Ohta T, Katagiri T, Ohtsuru S, Koike K, Ogawa S, Toi M, Iwata H, Nakamura S, Matsuo K, Takata M.
Cancer Med., 12(6), p.6549-6602 - Sodium ion influx regulates liquidity of biomolecular condensates in hyperosmotic stress response
Morishita, K., Watanabe, K., Naguro I.and Ichijo H
Cell Rep., 42(4), p.112315 - Development of fluorogenic substrates for colorectal tumor-related neuropeptidases for activity-based diagnosis
Nagano N, Ichihashi Y, Komatsu T, Matsuzaki H, Hata K, Watanabe T, Misawa Y, Suzuki M, Sakamoto S, Kagami Y, Kashiro A, Takeuchi K, Kanemitsu Y, Ochiai H, Watanabe R, Honda K and Urano Y
Chem. Sci., 14(17), p.4495-4499 - The crucial role of muscle glucocorticoid signaling in accelerating obesity and glucose intolerance via hyperinsulinemia.
Yamazaki H, Uehara M, Yoshikawa N, Kuribara-Souta A, Yamamoto M, Hirakawa Y, Kabe Y, Suematsu M, Tanaka H
JCI insight, 8(8), e162382 - Meeting Report: Wnt 2022 EMBO| The Company of Biologists Workshop and Yamada Conference
Kikuchi A, Takagi J, Takada S, Ishitani T, Minami Y
Genes Cells, 28(4), p.212-219 - Brg1 controls stemness and metastasis of pancreatic cancer through regulating hypoxia pathway
Araki O, Tsuda M, Omatsu M, Namikawa M, Sono M, Fukunaga Y, Masuda T, Yoshikawa T, Nagao M, Ogawa S, Masuo K, Goto N, Muta Y, Hiramatsu Y, Maruno T, Nakanishi Y, Koyasu S, Masui T, Hatano E, Saur D, Fukuda A, Seno H
Oncogene, 42(26), p.2139-2152 - LAT1 expression influences Paneth cell number and tumor development in ApcMin/+ mice
Sui Y, Hoshi N, Ohgaki R, Kong L, Yoshida R, Okamoto N, Kinoshita M, Miyazaki H, Ku Y, Tokunaga E, Ito Y
J Gastroenterol., 58(5), p.444-457 - p53-independent tumor suppression by cell-cycle arrest via CREB/ATF transcription factor OASIS
Saito A, Kamikawa Y, Ito T, Matsuhisa K, Kaneko M, Okamoto T, Yoshimaru T, Matsushita Y, Katagiri T, Imaizumi K
Cell Rep., 42(5), p.112479 - Expression of Ferredoxin1 in cisplatin-resistant ovarian cancer cells confers their resistance against ferroptosis induced by cisplatin
Takahashi R, Kamizaki K, Yamanaka K, Terai Y, Minami Y
Oncol. Rep., 49(6), p.124 - Annexin A1 is a cell-intrinsic metalloregulator of zinc in human ILC2s
Irie M, Kabata H, Sasahara K, Kurihara M, Shirasaki Y, Kamatani T, Baba R, Matsusaka M, Koga S, Masaki K, Miyata J, Araki Y, Kikawada T, Kabe Y, Suematsu M, Yamagishi M, Uemura S, Moro K, Fukunaga K
Cell Rep., 42(6), p.112610 - Phase 1/2a clinical trial in ALS with ropinirole, a drug candidate identified by iPSC drug discovery
Morimoto S, Takahashi S, Ito D, Daté Y, Okada K, Kato C, Nakamura S, Ozawa F, Chyi CM, Nishiyama A, Suzuki N, Fujimori K, Kondo T, Takao M, Hirai M, Kabe Y, Suematsu M, Jinzaki M, Aoki M, Fujiki Y, Sato Y, Suzuki N, Nakahara J; Pooled Resource Open-Access ALS Clinical Trials Consortium; Okano H.
Cell Stem Cell., 30(6), p.766-780 - Bacterial induction of B cell senescence promotes age-related changes in the gut microbiota
Kawamoto S, Uemura K, Hori N, Takayasu L, Konish, Y, Katoh K, Matsumoto T, Suzuki M, Sakai Y, Matsudaira T, Adachi T, Ohtani N, Standley DM, Suda W, Fukuda S, Hara E.
Nat Cell Biol., 25(6), p.865-876 - Cellular senescence in white matter microglia is induced during ageing in mice and exacebrates the neuroinflammatory phenotype
Matsudaira T, Nakano S, Konishi Y, Kawamoto S, Uemura K, Kondo T, Sakurai K, Ozawa T, Hikida T, Komine O, Yamanaka K, Fujita Y, Yamashita T, Matsumoto T, Hara E.
Commun. Biol., 6(1), p.665 - High SLC20A1 Expression Indicates Poor Prognosis in Prostate Cancer
Okamoto T, Onaga C, Matsuoka I, Ozaki A, Matsuda C, Kasai T, Xiong Y, Harada Y, Sato T, Nakano Y, Mano Y, Miyazaki S, Ishiguro H, Sato K, Tamori S, Sasaki K, Ohno S, Akimoto K.
Cancer Diagn Progn., 3(4), p.439-448 - Innovative method for the diagnosis of bile duct lesions using a novel tapered-tip sheath system to facilitate biliary biopsies
Matsumori T, Uza N, Okada H, Shiokawa M, Maruno T, Kuwada T, Yoshida H, Yasuda M, Yamazaki H, Taura K, Hatano E, Kodama Y, Seno H
Gastrointest Endosc, 98(1), p.43-50 - Knockout of all ErbB-family genes delineates their roles in proliferation, survival, and migration
Matsuda K, Hirayama D, Hino N, Kuno S, Sakaue S. A, Miyawaki A, Matsuda M, Terai K,
Journal of Cell Science, 136(16), jcs261199 - Chromatin conformational changes at human satellite II contribute to the senescence phenotype in the tumor microenvironment
Miyata K, Zhou X, Nishio M, Hanyu A, Chiba M, Kawasaki H, Osako T, Ohno S, Ueno T, Maruyama R, Takahashi A
PNAS, 120(32), e2305046120 - Evolutionary histories of breast cancer and related clones
Nishimura T, Kakiuchi N, Yoshida K, Sakurai T, Kataoka TR, Kondoh E, Chigusa Y, Kawai M, Sawada M, Inoue T, Takeuchi Y, Maeda H, Baba S, Shiozawa Y, Saiki R, Nakagawa MM, Nannya Y, Ochi Y, Hirano T, Nakagawa T, Inagaki-Kawata Y, Aoki K, Hirata M, Nanki K, Matano M, Saito M, Suzuki E, Takada M, Kawashima M, Kawaguchi K, Chiba K, Shiraishi Y, Takita J, Miyano S, Mandai M, Sato T, Takeuchi K, Haga H, Toi M, Ogawa S
Nature, 620(7974), p.607-614 - High expression PKCλ and ALDH1A3 indicates a poor prognosis, and PKCλ is required for the asymmetric cell division of ALDH1A3-positive cancer stem cells in PDAC
Kasai T, Tamori S, Takasaki Y, Matsuoka I, Ozaki A, Matsuda C, Harada Y, Sasaki K, Ohno S, Akimoto K.
Biochem Biophys Res Commun., 20(669), p.85-94 - Simultaneous activation of Kras-Akt and Notch pathways induces extrahepatic biliary cancer via the mTORC1 pathway
Namikawa M, Fukuda A, Mizukoshi K, Iwane K, Kawai M, Yamakawa G, Omatsu M, Sono M, Masuda T, Araki O, Nagao M, Yoshikawa T, Ogawa S, Hiramatsu Y, Muta Y, Tsuda M, Maruno T, Nakanishi Y, Tsuruyama T, Taura K, Hatano E, Seno H.
J Pathol., 260(4), p.478-492 - Simultaneous measurement of nascent transcriptome and translatome using 4-thiouridine metabolic RNA labeling and translating ribosome affinity purification
Imai H, Utsumi D, Torihara H, Takahashi K, Kuroyanagi H, Yamashita A
Nucleic Acids Res., 51(14), e76 - Genetic and chemical targeting of the ATPase complex TIP48 and 49 impairs acute myeloid leukemia
Hattori A, Takamatsu-Ichihara E, Yamamoto Y, Fujita S, Yamagata K, Katsumoto T, Machida Y, Shinohara H, Murakami R, Kitabayashi I
Leukemia, 37(9), p.1812-1829 - ELF3 suppresses gallbladder cancer development through downregulation of the EREG/EGFR/mTOR complex 1 signalling pathway
Nakamura T, Nishikawa Y, Shiokawa M, Takeda H, Yokode M, Matsumoto S, Muramoto Y, Ota S, Yoshida H, Okada H, Kuwada T, Marui S, Matsumori T, Maruno T, Uza N, Kodama Y, Hatano E, Seno H.
J Pathol., 261(1), p.28-42 - Pancreatic RECK inactivation promotes cancer formation, epithelial-mesenchymal transition, and metastasis
Masuda T, Fukuda A, Yamakawa G, Omatsu M, Namikawa M, Sono M, Fukunaga Y, Nagao M, Araki O, Yoshikawa T, Ogawa S, Masuo K, Goto N, Hiramatsu Y, Muta Y, Tsuda M, Maruno T, Nakanishi Y, Masui T, Hatano E, Matsuzaki T, Noda M, Seno H.
J Clin Invest., 133(18), e161847 - THBS1-producing tumor-infiltrating monocyte-like cells contribute to immunosuppression and metastasis in colorectal cancer
Omatsu M, Nakanishi Y, Iwane K, Aoyama N, Duran A, Muta Y, Martinez-Ordoñez A, Han Q, Agatsuma N, Mizukoshi K, Kawai M, Yamakawa G, Namikawa M, Hamada K, Fukunaga Y, Utsumi T, Sono M, Masuda T, Hata A, Araki O, Nagao M, Yoshikawa T, Ogawa S, Hiramatsu Y, Tsuda M, Maruno T, Kogame T, Kasashima H, Kakiuchi N, Nakagawa MM, Kawada K, Yashiro M, Maeda K, Saito Y, Matozaki T, Fukuda A, Kabashima K, Obama K, Ogawa S, Sheibani N, Diaz-Meco MT, Moscat J, Seno H.
Nat Commun., 14(1), p.5534 - Association of Sarcopenia with a Poor Prognosis and Decreased Tumor-Infiltrating CD8-Positive T Cells in Pancreatic Ductal Adenocarcinoma: A Retrospective Analysis
Masuda S, Yamakawa K, Masuda A, Toyama H, Sofue K, Nanno Y, Komatsu S, Omiya S, Sakai A, Kobayashi T, Tanaka T, Tsujimae M, Ashina S, Gonda M, Abe S, Uemura H, Kohashi S, Inomata N, Nagao K, Harada Y, Miki M, Irie I, Juri N, Kanzawa M, Itoh T, Fukumoto T, Kodama Y
Ann Surg Oncol., 30(9), p.5776-5787 - A comprehensive analysis of tumor-stromal collagen in relation to pathological, molecular, and immune characteristics and patient survival in pancreatic ductal adenocarcinoma
Ashina S, Masuda A, Yamakawa K, Hamada T, Tsujimae M, Tanaka T, Toyama H, Sofue K, Shiomi H, Sakai A, Kobayashi T, Abe S, Gonda M, Masuda S, Inomata N, Uemura H, Kohashi S, Nagao K, Harada Y, Miki M, Juri N, Irie Y, Kanzawa M, Itoh T, Inoue J, Imai T, Fukumoto T, Kodama Y
J Gastroenterol., 58(10), p.1055-1067 - Complement factor D targeting protects endotheliopathy in organoid and monkey models of COVID-19
Kawakami E, Saiki N, Yoneyama Y, Moriya C, Maezawa M, Kawamura S, Kinebuchi A, Kono T, Funata M, Sakoda A, Kondo S, Ebihara T, Matsumoto H, Togami Y, Ogura H, Sugihara F, Okuzaki D, Kojima T, Deguchi S, Vallee S, McQuade S, Islam R, Natarajan M, Ishigaki H, Nakayama M, Nguyen CT, Kitagawa Y, Wu Y, Mori K, Hishiki T, Takasaki T, Itoh Y, Takayama K, Nio Y, Takebe T.
Cell Stem Cell., 30(10), p.1315-1330 - Visual quantification of prostaglandin E2 discharge from a single cell
Watabe T, Yamahira S, Matsuda M, Terai, K.
Cell Struct Funct., 48(2), p.241-249 - Rho family small GTPase Rif regulates Wnt5a-Ror1-Dvl2 signaling and promotes lung adenocarcinoma progression
Nishita M, Kamizaki K, Hoshi K, Aruga K, Nishikaku I, Shibuya H, Matsumoto K, Minami Y
J Biol Chem., 299(10), p.105248 - Accumulation of annexin A2 and S100A10 prevents apoptosis of apically delaminated, transformed epithelial cells
Ito S, Kuromiya K, Sekai M, Sako H, Sai K, Morikawa R, Mukai Y, Ida Y, Anzai M, Ishikawa S, Kozawa K, Shirai T, Tanimura N, Sugie K, Ikenouchi J, Ogawa M, Naguro I, Ichijo H, Fujita Y
Proc Natl Acad Sci USA., 120(43), e2307118120 - A gut microbial metabolite of linoleic acid ameliorates liver fibrosis by inhibiting TGF-β signaling in hepatic stellate cells
Kasahara N, Imi Y, Amano R, Shinohara M, Okada K, Hosokawa Y, Imamori M, Tomimoto C, Kunisawa J, Kishino S, Ogawa J, Ogawa W, Hosooka T.
Sci Rep., 13(1), p.18983 - Synthetic augmentation of bilirubin metabolism in human pluripotent stem cell-derived liver organoids
Reza HA, Farooqui Z, Reza AA, Conroy C, Iwasawa K, Ogura Y, Okita K, Osafune K, Takebe T.
Stem Cell Reports, 18(11), p.2071-2083 - Wnt activation disturbs cell competition and causes diffuse invasion of transformed cells through NF-κB-MMP21 pathway
Nakai K, Lin H, Yamano S, Tanaka S, Kitamoto S, Saitoh H, Sakuma K, Kurauchi J, Akter E, Konno M, Ishibashi K, Kamata R, Ohashi A, Koseki J, Takahashi H, Yokoyama H, Shiraki Y, Enomoto A, Abe S, Hayakawa Y, Ushiku T, Mutoh M, Fujita Y, Kon S
Nature Communications, 14(1), p.7048 - YBX1 regulates satellite II RNA loading into small extracellular vesicles and promotes the senescent phenotype
Chiba M, Miyata K, Okawa H, Tanaka Y, Ueda T, Seimiya H, Takahashi A
Int J Mol Sci., 24(22), p.16399 - A novel endoscopy training system by video-based asynchronous communication
Inoue T, Utsumi T, Agatsuma N, Nishikawa Y, Soshi M, Sano Y, Seno H.
Endoscopy, 55(S01), E307-E309 - Head-to-head comparison of three chelates reveals DOTAGA promising for 225 Ac labeling of anti-FZD10 antibody OTSA101
Sudo H, Tsuji AB, Sugyo A, Harada Y, Nagayama S, Katagiri T, Nakamura Y, Higashi T
Cancer Sci., 114(12), p.4677-4690 - TOLLIP acts as a cargo adaptor to promote lysosomal degradation of aberrant ER membrane proteins
Hayashi Y, Takatori S, Warsame WY, Tomita T, Fujisawa T, Ichijo H
EMBO J., 42(23), e114272 - miR-125a-5p/miR-125b-5p contributes to pathological activation of angiotensin II-AT1R in mouse distal convoluted tubule cells by the suppression of Atrap
Hirota K, Yamashita A, Abe E, Yamaji T, Azushima K, Tanaka S, Taguchi S, Tsukamoto S, Wakui H, Tamura K
J Biol Chem., 299(12), p.105478
- Common germline risk variants impact somatic alterations and clinical features across cancers