研究成果
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原著論文
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木暮 泰寛、亀田 拓郎、古屋 淳史、吉満 誠、野坂 生郷、安永 純一朗、今泉 芳孝、渡邊 瑞希、斎藤 優樹、伊藤 勇太、Marni B. McClure、田畑 真梨子、新垣 清登、吉藤 康太、千葉 健一、岡田 愛、垣内 伸之、南谷 泰仁、上運天 綾子、田平 優貴、秋月 渓一、関根 雅明、幣 光太郎、日高 智徳、久冨木 庸子、北中 明、日高 道弘、中野 伸亮、宇都宮 與、R. Alejandro Sica、Ana Acuna-Villaorduna、Murali Janakirum、Urvi Shah、Juan Carlos Ramos、柴田 龍弘、竹内 賢吾、高折 晃史、宮﨑 泰司、松岡 雅雄、石塚 賢治、白石 友一、宮野 悟、小川 誠司、B. Hilda Ye、下田 和哉、片岡 圭亮, Whole-genome landscape of adult T-cell leukemia/lymphoma. Blood, 2022, 139(7), p.967-982
Okada H, Takahashi K, Yaku H, Kobiyama K, Iwaisako K, Zhao X, Shiokawa M, Uza N, Kodama Y, Ishii KJ, Seno H., In situ vaccination using unique TLR9 ligand K3-SPG induces long-lasting systemic immune response and synergizes with systemic and local immunotherapy, Sci Rep., 2022, 12(1), p.2132
Takeda H, Takai A, Eso Y, Takahashi K, Marusawa H, Seno H., Genetic Landscape of Multistep Hepatocarcinogenesis, Cancers, 2022, 14(3), p.568
Komatsu S, Yano Y, Fujishima Y, Ishida J, Kido M, Kuramitsu K, Yamamoto A, Goto T, Yanagimoto H, Toyama H, Ueda Y, Kodama Y, Fukumoto T. , Current Role of Atezolizumab Plus Bevacizumab Therapy in the Sequential Treatment of Unresectable Hepatocellular Carcinoma. Anticancer Res., Anticancer Res., 2022, 42(3), p.1403-1412
Yamauchi Y, Kodama Y, Kakiuchi N, Seno H., Multiple pancreatic neuroendocrine tumors in OFCD syndrome caused by somatic BCOR mosaicism., Pancreatology., 2022, 22(2), p.335-337
Jun Akatsuka, Yasushi Numata, Hiromu Morikawa, Tetsuro Sekine, Shigenori Kayama, Hikaru Mikami, Masato Yanagi, Yuki Endo, Hayato Takeda, Yuka Toyama, Ruri Yamaguchi, Go Kimura, Yukihiro Kondo, Yoichiro Yamamoto, A data-driven ultrasound approach discriminates pathological high grade prostate cancer, Scientific Reports, 2022, 12(860)
Ichise, H. Tsukamoto, S. Hirashima, T. Konishi, Y. Oki, C. Tsukiji, S. Iwano, S. Miyawaki, A. Sumiyama, K. Terai, K. Matsuda, M., Functional visualization of NK Cell-mediated killing of metastatic single tumor cells, eLife, 2022, 11
Nakada A, Maruyama T, Kamiya M, Hanaoka K, Urano Y., Rapid Visualization of Deeply Located Tumors In Vivo by Intravenous Administration of a γ-Glutamyltranspeptidase-Activated Fluorescent Probe., Bioconjug. Chem., 2022, 33, p.523-529
Kuriki Y, Yoshioka T, Kamiya M, Komatsu T, Takamaru H, Fujita K, Iwaki H, Nanjo A, Akagi Y, Takeshita K, Hino H, Hino R, Kojima R, Ueno T, Hanaoka K, Abe S, Saito Y, Nakajima J, Urano Y, Development of a fluorescent probe library enabling efficient screening of tumour-Imaging probes based on discovery of biomarker enzymatic activities., Chem. Sci., 2022, 16, p.4474-4481
Tsuji S, Minami S, Hashimoto R, Konishi Y, Suzuki T, Kondo T, Sasai M, Torii S, Ono C, Shichinohe S, Sato S, Wakita M, Okumura S, Nakano S, Matsudaira T, Matsumoto T, Kawamoto S, Yamamoto M, Watanabe T, Matsuura Y, Takayama K, Kobayashi T, Okamoto T, & Hara, E., SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response., Nature Aging, 2022, 2, p.115-124
Konishi, Y., Okumura, S., Matsumoto, T., Itatani, Y., Nishiyama T., Okazaki, Y., Shibutani, M., Ohtani, N., Nagahara, H., Obama, K., Ohira, M., Sakai, Y.., Nagayama, S. & Hara, E., Development and evaluation of a colorectal cancer screening method using machine learning-based gut microbiota analysis., Cancer Medicine, 2022, 0, p.1-13
Tsuchihashi K, Hirata Y, Yamasaki J, Suina K, Tanoue K, Yae T, Masuda K, Baba E, Akashi K, Kitagawa Y, Saya H, Nagano O, Presence of spontaneous epithelial-mesenchymal plasticity in esophageal cancer., Biochem Biophys Rep., 2022, 19(30), p.101246
Rina Nagata, Nanami Akai, Shu Kondo, Kuniaki Saito, Shizue Ohsawa, Tatsushi Igaki, Yorkie drives supercompetition by non-autonomous induction of autophagy via bantam microRNA in Drosophila, Current Biology, 2022, 32(5), p.1064-1076
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招待講演
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片桐豊雅, がん抑制因子活性化ペプチド創薬, 第17回日本がん分子標的治療学会TRワークショップ, 2022/01
片桐豊雅, 乳がん治療刷新を目指した新たな創薬開発研究, 第137回日本病理学会中国四国支部学術集会, 2022/02
Eiji Hara, Cellular senescence and cancer:a gut microbial connection, Next Frontiers in Aging Research Symposium , 2022/01
原 英二, 細胞老化と癌:微生物の関与について, 心・腎・代謝領域 Scientific Exchange Meeting, 2022/02
Eiji Hara, Roles and Mechanisms of Cellular Senescence in Inflammation and Cancer, Keystone Symposium, 2022/03
一條秀憲, 分子クラウディングとLLPS による浸透圧センシング, 第127回日本解剖学会総会, 2022/03
高橋 暁子, がん微小環境における細胞老化の機能, 第40回腫瘍病理セミナー・北信がんプロFD講演会・金沢女性研究者フォーラム, 2022/01
高橋 暁子, 細胞老化の生体機能, 京都大学薬学研究セミナー:未踏薬学領域を切り開く創発科学とは, 2022/01
高橋 暁子, Molecular mechanisms of inflammatory gene expression in senescent cells, The 12th BRI International Symposium「The old and new crossroads of microorganisms and neurodegeneration」, 2022/02
高橋 暁子, 細胞老化と発がん, 第40回サイトプロテクション研究会, 2022/03
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その他著作物(総説、書籍など)
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脇田将裕、原 英二,
細胞老化現象に着目した新たながん治療戦略, 実験医学, 2022, vol.40, p.371-376Kondoh, H. & Hara, E.,
Targeting p21 for diabetes: Another choice of senotherapy, Cell Metabolism, 2022, vol34, p.5-7Miyata, K. and Takahashi, A.,
Pericentromeric repetitive ncRNA regulates chromatin interaction and inflammatory gene expression., Nucleus, 202202, vol. 13(No. 1), p.3/14/00-3/18/00Endo, M., Kamizaki, K., and Minami, Y.,
The Ror-family receptors in development, tissue regeneration and age-related disease. , Front. Cell Dev. Biol., 2022, vol. 10
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