研究成果

原著論文
- Modular Design Platform for Activatable Fluorescence Probes Targeting Carboxypeptidases Based on ProTide Chemistry
  Kuriki Y, Sogawa M, Komatsu T, Kawatani M, Fujioka H, Fujita K, Ueno T, Hanaoka K, Kojima R, Hino R, Ueo H, Ueo H, Kamiya M, Urano Y
  J. Am. Chem. Soc., 2024, 146(1), p.521-531
  
  Luminal B breast cancer coexpressing p62 and ALDH1A3 is less susceptible to radiotherapy.
  Ozaki A, Matsuda A, Maemura Y, Tada Y, Kasai T, Nagashima Y, Onaga C, Hara Y, Kitabatake K, Tsukimoto M, Tamori S, Sasaki K, Ohno S, Akimoto K.
  Anticancer Res., 2024, 44(1), p.37-47
  
  Calcium transients trigger switch-like discharge of prostaglandin E₂ in an extracellular signal-regulated kinase-dependent manner
  Yamahira S, Takakura K, Thumkeo D, Narumiya S, Matsuda M, Terai K
  eLife, 2024, 12, RP86727
  
  Machine Learning of Histopathological Images Predicts Recurrences of Resected Pancreatic Ductal Adenocarcinoma With Adjuvant Treatment
  Yamaguchi R, Morikawa H, Akatsuka J, Numata Y, Noguchi A, Kokumai T, Ishida T, Mizuma M, Morikawa T, Unno M, Miyake A, Tamiya G, Yamamoto Y, Furukawa T
  Pancreas, 2024, 53(2), e.199-204
  
  Stress-induced stenotic vascular remodeling via reduction of plasma omega-3 fatty acid metabolite 4-oxoDHA by noradrenaline
  Nishimori M, Hayasaka N, Otsui K, Inoue N, Asakura J, Nagao M, Toh R, Ishida T, Hirata KI, Furuyashiki T, Shinohara M.
  Sci Rep, 2024, 20(14), p.4178
  
  Repositioning of mifepristone as an integrated stress response activator to potentiate cisplatin efficacy in non-small cell lung cancer
  Namkaew J, Zhang J, Yamakawa N, Hamada Y, Tsugawa K, Oyadomari M, Miyake M, Katagiri T, Oyadomari S.
  Cancer Lett, 2024, 1(582), 216509
  
  Impact of intratumoral microbiome on tumor immunity and prognosis in human pancreatic ductal adenocarcinoma
  Toyama H, Sakai A, Kobayashi T, Tanaka T, Tsujimae M, Yamakawa K, Gonda M, Masuda S, Uemura H, Kohashi S, Inomata N, Nagao K, Harada Y, Miki M, Irie Y, Juri N, Ko T, Yokotani Y, Oka Y, Ota S, Kanzawa M, Itoh T, Imai T, Fukumoto T, Hara E, Kodama Y.
  J Gastroenterol., 2024, 59(3), p.250-262
  
  Mechanical convergence in mixed populations of mammalian epithelial cells
  Gauquelin, E., Kuromiya, K., Namba, T., Ikawa, K., Fujita, Y., Ishihara, S., and Sugimura, K.
  Eur Phys J E Soft Matter, 2024, 47(3), p.21
  
  Developmental conversion of thymocyte-attracting cells into self-antigen-displaying cells in embryonic thymus medulla epithelium
  Ohigashi I, White AJ, Yang MT, Fujimori S, Tanaka Y, Jacques A, Kiyonari H, Matsushita Y, Turan S, Kelly MC, Anderson G, Takahama Y
  Elife, 2024, 12(2), RP.92552
  
  Co-expression of SLC20A1 and ALDH1A3 is associated with poor prognosis, and SLC20A1 is required for the survival of ALDH1-positive pancreatic cancer stem cells.
  Matsuoka I, Kasai T, Onaga C, Ozaki A, Motomura H, Maemura Y, Tada Y, Mori H, Hara Y, Xiong Y, Sato K, Tamori S, Sasaki K, Ohno S, Akimoto K.
  Oncol Lett., 28(3), p.426
  
  Pan-cancer comparative and integrative analyses of driver alterations using Japanese and international genomic databases.
  NHorie S, Saito Y, Kogure Y, Mizuno K, Ito Y, Tabata M, Kanai T, Murakami K, Koya J, Kataoka K.
  Cancer Discov., 2024, 14(5), p.786-803
  
  Role of Wnt5b-Ror1 signaling in the proliferation of pancreatic ductal adenocarcinoma cells
  Yamauchi N, Otsuka M, Ishikawa T, Kakeji Y, Kikuchi A, Masuda A, Kodama Y, Minami Y, Kamizaki K.
  Genes Cells, 2024, 29(6), p.503-511

招待講演

武部貴則	Disrupt or Develop− 新しい医療への道	TMDU消化器内科講演会	2024/1/6
Eiji Hara	Role of cellular senescence in aging and cancer: relationship with microorganisms	A3-FORESIGHT	2024/1/11
武部貴則	オルガノイド医療の可能性	第57回日本成人病（生活習慣病）学会	2024/1/14
一條秀憲	細胞がストレスを感じる仕組みと疾患〜分子クラウディングとLLPSによる浸透圧センシング、他〜	岡山大学大学院講義	2024/1/16
Yasuteru Urano	Chemical Medicine: Development of novel chemistry-based theranostics technologies for cancer	The 11th Takeda Science Foundation Symposium on PharmSciences	2024/1/26
Hiroshi Seno	Models for digestive organ tumors: from precursor to intractable cancer	Kyoto Winter School 2024	2024/2/21
片岡圭亮	Genetic alterations and their clinical significance in mature lymphoid neoplasms	第21回日本臨床腫瘍学会学術集会	2024/2/23
原　英二	がんと老化における細胞老化の役割 : 腸内細菌の関与について	第４回福島県腸内細菌学術講演会	2024/3/1
多森翔馬	Mutual information-based screening identifies gene signature for late recurrence in luminal A breast cancer	The 10th International Postgraduate Conference on Pharmaceutical Sciences 2022	2024/3/6
原　英二	細胞老化のメカニズムと役割ー細胞老化研究の光と影ー	第27回アディポサイエンス・シンポジウム	2024/3/8
原　英二	細胞老化の仕組みと役割	第２回STROMA研究会	2024/3/20
武部貴則	オルガノイドを用いた器官創生への展望	第31回日本医学会総会	2024/4/22

研究成果

原著論文

招待講演